If you're looking for a place to get away, look no further than Cayo Guillermo. Whether you're planning to stay for a night or for the week, the area around Cayo Guillermo has accommodation options to fit every need. Search for hotels in Cayo Guillermo with Hotels.com by checking our online map. Our map displays the areas and neighbourhoods around all Cayo Guillermo hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Cayo Guillermo hotel deals are here with our lowest price guarantee.