Hilton Jacksonville At Mayo Clinic

Luxury hotel in Jacksonville with outdoor pool and restaurant

Choose dates to view prices

Tue, Feb 17
Sat, Feb 21
February 2026
16
March 2026
When you stay at Hilton Jacksonville At Mayo Clinic, you'll be within a 10-minute drive of Mayo Clinic Florida and St. Johns Town Center. The outdoor pool is a great spot to take a dip, and guests can grab a bite to eat at Coastal Kitchen, which serves American cuisine and is open for breakfast, lunch, and dinner. Other highlights at this luxurious hotel include a fitness center and a bar/lounge.
Exceptional

Popular amenities

  • Pool
  • Free parking
  • Free WiFi
  • Restaurant
  • Air conditioning
  • Gym

Main amenities (12)

  • Daily housekeeping
  • Restaurant and bar/lounge
  • Outdoor pool
  • Breakfast available
  • Free area shuttle
  • Fitness center
  • Room service
  • 12 meeting rooms
  • Meeting rooms
  • 24-hour front desk
  • Air conditioning
  • Convenience store

For families (6)

  • Children stay free
  • Free cribs/infant beds
  • Premium TV channels
  • Daily housekeeping
  • Laundry facilities
  • Coffee/tea maker
$183 nightly
$208 total
Feb 20 - Feb 21
Total with taxes and fees

Room options

Showing 20 of 20 rooms
Bathroom shower
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Room, 1 King Bed | Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed

Wonderful

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Sleeps 2
  • 1 King Bed
Lake view
View from room
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Deluxe Room, 1 King Bed (Water View)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Sofa bed
  • Water view
  • Sleeps 2
  • 1 King Bed
Lake view
View from room
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Sleeps 2
  • 1 King Bed
Bathroom shower
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Sofa bed
  • Sleeps 4
  • 1 King Bed
Bathroom shower
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Corner

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Sofa bed
  • Sleeps 4
  • 1 King Bed
Hair dryer, towels, soap, shampoo
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Sleeps 2
  • 1 King Bed
Hair dryer, towels, soap, shampoo
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Sleeps 2
  • 1 King Bed
Hair dryer, towels, soap, shampoo
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Sleeps 2
  • 1 King Bed
Bathroom shower
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Zero Count)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Sleeps 2
  • 1 King Bed
Lake view
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View)

Wonderful

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Water view
  • Sleeps 2
  • 1 King Bed
Lake view
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Room, 1 King Bed (Water View, Roll-In Shower) | Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View, Roll-In Shower)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Water view
  • Sleeps 2
  • 1 King Bed
Bathroom shower
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Sleeps 2
  • 1 King Bed
Hair dryer, towels, soap, shampoo
Room, 1 King Bed, Accessible (Roll-In Shower) | Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Room, 1 King Bed, Accessible (Roll-In Shower) | Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Roll-In Shower)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Sleeps 2
  • 1 King Bed
Bathroom shower
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Sleeps 2
  • 1 King Bed
Bathroom shower
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds

Exceptional

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Sleeps 4
  • 2 Queen Beds
Lake view
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Water View, Hearing)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Water view
  • Sleeps 4
  • 2 Queen Beds
Accessible bathroom
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Room, 2 Queen Beds, Accessible, Bathtub | Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub

Exceptional

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Sleeps 4
  • 2 Queen Beds
Bathroom shower
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Hearing)

Very good

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Sleeps 4
  • 2 Queen Beds
Lake view
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds (Water View)

Exceptional

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Water view
  • Sleeps 4
  • 2 Queen Beds
Lake view
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub (View)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Blackout drapes/curtains
Premium bedding
Hair dryer
  • Sleeps 4
  • 2 Queen Beds

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About the neighborhood

Map
4745 Transformation Way, Jacksonville, FL, 32224

What's nearby

  • Mayo Clinic Florida - 1 min walk - 0.0 km
  • St. Johns Town Center - 7 min drive - 10.9 km
  • TPC Sawgrass - 12 min drive - 14.7 km
  • Mayport Naval Station - 17 min drive - 18.9 km
  • Jacksonville Naval Air Station - 29 min drive - 47.0 km

Getting around

  • Jacksonville, FL (CRG-Jacksonville Executive at Craig) - 14 min drive
  • Jacksonville International Airport (JAX) - 33 min drive
  • St. Augustine, FL (UST-Northeast Florida Regional) - 41 min drive
  • Jacksonville Station - 28 min drive
  • Free area shuttle

Restaurants

  • ‪Culver’s - ‬3 min drive
  • ‪Starbucks - ‬3 min drive
  • ‪Circle K - ‬16 min walk
  • ‪M Brothers at Mayo - ‬14 min walk
  • ‪Starbucks - ‬13 min walk

About this property

Hilton Jacksonville At Mayo Clinic

When you stay at Hilton Jacksonville At Mayo Clinic, you'll be within a 10-minute drive of Mayo Clinic Florida and St. Johns Town Center. The outdoor pool is a great spot to take a dip, and guests can grab a bite to eat at Coastal Kitchen, which serves American cuisine and is open for breakfast, lunch, and dinner. Other highlights at this luxurious hotel include a fitness center and a bar/lounge.

At a glance

Hotel size

    • 252 rooms
    • Arranged over 8 floors

Arriving/Leaving

    • Check-in start time: 4:00 PM; Check-in end time: 5:00 AM
    • Express check-out available
    • Late check-in subject to availability
    • Minimum check-in age: 21
    • Check-out time is 11:00 AM
    • Contactless check-out available

Special check-in instructions

    • Front desk staff will greet guests on arrival at the property
    • If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
    • The credit card used to book the reservation must be presented by the cardholder at check-in along with matching photo identification, and other arrangements must be coordinated with the property prior to arrival
    • Information provided by the property may be translated using automated translation tools

Required at check-in

    • Credit card required for incidental charges
    • Government-issued photo ID may be required
    • Minimum check-in age is 21

Children

    • Up to 2 children (18 years old and younger) stay free, per registered adult, when occupying the parent or guardian's room, using existing bedding

Pets

    • Pets not allowed

Internet

    • Free WiFi in public areas
    • Free WiFi in rooms (speed: 25+ Mbps)

Parking

    • Free uncovered onsite self parking
    • Electric vehicle charging point on site

Offsite

    • Free area shuttle within 350 yards

Other information

    • Smoke-free property

Property amenities

Food and drink

  • Buffet breakfast (surcharge) each morning 6:00 AM–10:30 AM
  • Restaurant
  • Bar/lounge
  • Room service (late night)

Traveling with children

  • Children stay free (see details)
  • Free local shuttle
  • Grocery/convenience store
  • Children's menu

Working away

  • 12 meeting rooms
  • Coworking spaces
  • Conference space (20000 square feet)

Services

  • 24-hour front desk
  • Concierge services
  • Dry cleaning/laundry services
  • Luggage storage
  • Wedding services
  • Porter/bellhop
  • Pool loungers
  • Pool umbrellas
  • Romance packages

Facilities

  • 1 building/tower
  • Built in 2025
  • Television in common areas
  • Fitness center
  • An outdoor pool
  • At least 80% of food locally-sourced
  • Vegetarian dining options
  • At least 80% lighting from LEDs
  • Comprehensive food waste policy
  • Firepit
  • Outdoor furniture
  • Traditional architecture

Accessibility

  • Tile flooring in public areas

Room amenities

Be entertained

  • 55-inch Smart TV
  • Premium cable channels
  • Netflix
  • Streaming services

Home comfort

  • Air conditioning and heating
  • Coffee/tea maker
  • Iron/ironing board

Sleep well

  • Blackout drapes/curtains
  • Premium bedding
  • Free crib/infant bed
  • Rollaway/extra bed (surcharge)

Freshen up

  • Bathtub or shower
  • Soap and shampoo
  • Hair dryer
  • Towels
  • Toilet paper

Stay connected

  • Free WiFi (speed of 25+ Mbps)
  • Free long-distance and local calls

Food and drink

  • Mini-fridge
  • Free bottled water

More

  • Daily housekeeping
  • In-room safe (laptop compatible)
  • LED light bulbs
  • Recycling
  • Water-efficient showers only
  • Water-efficient toilets only
  • Mobile key entry
  • Local maps

Special features

Dining

Coastal Kitchen - This restaurant specializes in American cuisine and serves breakfast, lunch, and dinner. Guests can enjoy drinks at the bar. A children's menu is available.
Coastal Kitchen Bar - Onsite cocktail bar. Open daily.

Fees & policies

Refundable deposits

  • Breakage deposit: USD 100 per stay

Optional extras

  • Buffet breakfast is offered for an extra charge of approximately USD 26.99 to 26.99 for adults, and USD 15 to 21 for children

Children & extra beds

  • Rollaway beds are available for USD 50.00 per night

Pool, spa, & gym (if applicable)

  • Pool access available from 8:00 AM to 10:00 PM
  • Guests under 16 years old are not allowed in the fitness facility, and guests under 16 years old are only allowed in the swimming pool with adult supervision

Policies

Only registered guests are allowed in the guestrooms.
Guests can rest easy knowing there's a carbon monoxide detector and a smoke detector on site.
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation.
This property accepts credit cards and debit cards. Cash is not accepted.
Credit cards accepted: Visa, Mastercard, American Express, Discover, Diners Club, Carte Blanche
Cashless transactions are available.
This property reserves the right to pre-authorize the guest's credit card prior to arrival.

Also known as

Hilton Jacksonville At Mayo Clinic Hotel
Hilton Jacksonville At Mayo Clinic Jacksonville
Hilton Jacksonville At Mayo Clinic Hotel Jacksonville

Frequently asked questions

Is there a pool at Hilton Jacksonville At Mayo Clinic?

Yes, there's an outdoor pool. Guests have pool access from 8:00 AM to 10:00 PM.

Are pets allowed at Hilton Jacksonville At Mayo Clinic?

Sorry, pets aren't allowed.

Is parking offered on site at Hilton Jacksonville At Mayo Clinic?

Yes, there's free self parking. Electric vehicle charging is available.

What are the check-in and check-out times at Hilton Jacksonville At Mayo Clinic?

Check-in start time: 4:00 PM; Check-in end time: 5:00 AM. Check-out time is 11:00 AM. Express check-out and contactless check-out are available.

What is there to do at Hilton Jacksonville At Mayo Clinic and nearby?

Hilton Jacksonville At Mayo Clinic has an outdoor pool and a fitness center.

Are there restaurants at or near Hilton Jacksonville At Mayo Clinic?

Yes, Coastal Kitchen offers American cuisine.

What's the area around Hilton Jacksonville At Mayo Clinic like?

Hilton Jacksonville At Mayo Clinic is located a short 6-minute walk from Mayo Clinic Florida.

Have a question?

Get instant answers with AI powered search of property information and reviews.

Hilton Jacksonville At Mayo Clinic Reviews

9.6

Exceptional

10

Cleanliness

9.6

Amenities

9.8

Staff & service

10

Property conditions & facilities

10/10 Exceptional

The staff and hotel were wonderful!
Shaunte, 1-night trip

10/10 Exceptional

Room was spotless, amenities were great, and staff was super nice!
Mark, 5-night trip

10/10 Exceptional

Everything was GREAT!!!
Sharika, 1-night trip

10/10 Exceptional

Excellent stay from start to finish. Very nice overall.
Gonzalo, 1-night trip

10/10 Exceptional

The rooms were clean. Bar staff were wonderful, great personalities.
Melissa, 3-night trip

10/10 Exceptional

Friendly welcoming staff at the front desk and the restaurant! Immaculate! Comfy bedding and pillows!
Diane, 1-night trip

10/10 Exceptional

Everything was exceptional!
Melody, 2-night trip

10/10 Exceptional

Wonderful!
Erin, 1-night trip

10/10 Exceptional

Great staff and rooms
Albert, 1-night trip

10/10 Exceptional

Very nice hotel. Food is excellent and friendly staff.
Erron, 2-night trip

10/10 Exceptional

Very nice hotel
Laurie, 4-night trip

10/10 Exceptional

Clean, comfortable, nice restaurant & coffee shop.
Joahnna, 3-night trip

10/10 Exceptional

Great location
gurpreet, 1-night trip

10/10 Exceptional

Beautiful hotel! Very comfortable beds. Spotless!! Definitely recommend. A+++++
Catherine, 1-night trip

10/10 Exceptional

Gorgeous brand new hotel.
Christine, 2-night trip

8/10 Very good

The staff were courteous, the amenities fantastic. Only problem was a clump of hair from a previous guest found in the shower.
Tristan, 1-night trip

10/10 Exceptional

excellent staff'
Michael, 1-night trip

10/10 Exceptional

The overall experience was excellent. The room was well maintained and clean. The staff were extremely helpful and accommodating. The experience was so positive that earlier today I booked a stay at a Hilton in the city of a conference I will be attending in the Spring.
JoAnn, 2-night trip

10/10 Exceptional

Room was spotless, new hotel, wonderful friendly staff
Cathy, 1-night trip

10/10 Exceptional

Staff was friendly. Room was clean. Little wait at checkin. Bed was great!
Jo-Ann, 1-night trip

10/10 Exceptional

Staff was courteous. Room was clean and comfortable. Everything looked brand new. Very clean. Beautiful hotel. Will definitely go back.
Jose, 2-night trip

10/10 Exceptional

Very nice facility and staff. Would recommend to anyone visiting the Mayo Clinic.
Shearn, 2-night trip

10/10 Exceptional

This is by far the best Hilton in the country. Super modern, clean and classy. The room was also super nice, clean and spacious.
Shahriar, 1-night trip

8/10 Very good

Clean room.
Lee, 1-night trip

10/10 Exceptional

Everything was great
Kamale, 3-night trip